Interaction check
Piperine Drug Interactions: Black Pepper Extract Explained
Piperine drug interactions come from one idea: piperine, the compound in black pepper, can raise how much of a drug reaches the blood. A small 1991 study with six healthy people per group saw this with propranolol and theophylline. Quietum Plus lists piperine with no amount, so ask your doctor or pharmacist if you take medicine.
Written by the Quietum Plus label deskUpdated · 4 min read
What are the drug interactions of piperine?
Piperine can raise the amount of some drugs that reach your blood. That is the interaction researchers have measured, and it is why doctors ask about it.
In a small crossover study, healthy volunteers took propranolol or theophylline alone, then with piperine for 7 days. With piperine, both drugs showed higher peak levels and total exposure. Theophylline also stayed in the body longer (Bano et al., Piperine and Propranolol).
The authors read this as better availability of both drugs. Only six people were in each group, and it was a single-dose design from 1991. It does not cover other drugs, and it did not test Quietum Plus.
| Drug | Used for | With piperine |
|---|---|---|
| Propranolol | Blood pressure, heart rhythm | Higher peak and total levels |
| Theophylline | Asthma, lung disease | Higher levels, slower clearance |
| Other drugs | Varies | Not covered |
Why does a higher drug level matter?
A higher level can mean stronger effects or more side effects from the same prescribed dose. That matters most for drugs with a narrow safe range.
We cannot tell you which of your medicines are affected. Only your prescriber knows your drugs, your doses and your lab results. That is why the question to ask is about the whole list.
Keep taking prescribed medicine. Do not skip or change a dose to make room for a supplement.
- List every medicine, vitamin and herb you use.
- Ask your pharmacist to check piperine and the other ingredients together.
- Report new dizziness, a racing heart or breathing changes right away (NCCIH, Using Dietary Supplements Wisely).
Is piperine used for tinnitus?
No source we cite connects piperine to tinnitus or hearing. It is used in supplements mainly to help other ingredients absorb, which is also why it deserves a second look.
Ringing needs its own plan. The 2026 guideline advises clinicians not to recommend supplements for persistent, bothersome tinnitus (AAO-HNSF Tinnitus Update 2026). See a doctor for sudden hearing loss in one ear, ringing that beats with your pulse, ringing after a head injury, or ringing with dizziness, weakness or a drooping face. Face weakness is an emergency.
If you suspect one, ask your prescriber. Do not stop it on your own.
Quietum Plus: from $49 a bottle60 capsules a bottle · 2, 3 or 6 bottles · 60-day money-back guarantee
See packsHow does Quietum Plus list piperine?
Piperine sits on the sixth sales-page tile with ashwagandha. Quietum Plus is a capsule supplement, 60 per bottle. The images we reviewed show no Supplement Facts panel, so the piperine amount, serving and warnings are not printed.
That gap makes an interaction hard to judge. The bottle front lists Clear Mind, Memory & Focus and Mood Support, not hearing. See the ashwagandha and piperine page and supplements and medicines.
Packs cost $79, $69 or $49 a bottle, with a 60-day money-back guarantee. Follow your bottle's label.
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Prices from the sales page, October 19, 2026 (Quietum Plus order section). Two bottles are $158 plus $9.99 shipping. Every pack carries the 60-day money-back guarantee. Check your medicines first.
01FAQ
Piperine questions
Is piperine the same as black pepper?
Piperine is the main pungent compound in black pepper. Eating pepper on food is different from taking a concentrated extract in a capsule. Labels may list it as piperine, black pepper extract or by a brand name, so read the ingredient list.
Does piperine affect all medicines?
No, and we do not claim it does. The study we cite tested two drugs, propranolol and theophylline. Other drugs were not covered. Ask your pharmacist to check your own list, since interactions depend on the drug.
Should I avoid piperine if I take blood pressure medicine?
Ask your doctor or pharmacist first. Propranolol, a blood pressure drug, reached higher levels with piperine in one small study. Do not change your medicine yourself, and bring the supplement bottle so they can review every ingredient.
02Who wrote this
Written and reviewed by
Pages built from the bottle images, the sales page and linked NIH, NIDCD, FDA, FTC and peer-reviewed sources.
Last updated . Read our editorial standards and how we check reviews. This website is run by Goquietumplus, a USA Authorized Quietum Plus Retailer, not by the manufacturer. We earn money when you buy through our order links.
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